Exploring how genetic factors influence inflammation and cognitive decline in aging
Investigating neutrophilic inflammation as an APOE genotype-specific mediator of neuroinflammation and cognitive decline in aging
This study is looking at how certain immune cells and genes might affect inflammation and memory loss in older adults with Alzheimer's, and it hopes to find new ways to help people based on their unique genetic backgrounds and gut health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mc Laughlin Research Institute NIH-funded |
| Lab location | 1 site (Great Falls, United States) |
| Project ID | NIH-11086773 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in the development of Alzheimer's disease, particularly focusing on how different genetic variations of the APOE gene affect inflammation and cognitive decline in older adults. The study aims to understand how neutrophil activation and lifespan can be targeted to potentially reduce the risk or progression of Alzheimer's disease. Additionally, it will explore the interactions between gut microbiota and the immune system, which may influence neuroinflammation and cognitive health. By examining these factors, the research seeks to uncover new therapeutic strategies tailored to individuals based on their genetic makeup.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults, particularly those with the APOE4 allele, who are at higher risk for Alzheimer's disease.
Not a fit: Patients without any APOE genetic variations or those who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments that reduce the risk of Alzheimer's disease and improve cognitive health in aging populations.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Great Falls, United States
- Mc Laughlin Research Institute — Great Falls, United States (Active)
Researchers
- Principal investigator: Hensley-Mcbain, Tiffany — Mc Laughlin Research Institute
- Study coordinator: Hensley-Mcbain, Tiffany
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.