Exploring how genetic factors influence inflammation and cognitive decline in aging
Official title: Investigating neutrophilic inflammation as an APOE genotype-specific mediator of neuroinflammation and cognitive decline in aging
Funded at Mc Laughlin Research Institute · NIH-11086773 · Data updated 2026-11-12
This study is looking at how certain immune cells and genes might affect inflammation and memory loss in older adults with Alzheimer's, and it hopes to find new ways to help people based on their unique genetic backgrounds and gut health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mc Laughlin Research Institute NIH-funded |
| Lab location | 1 site (Great Falls, United States) |
| Project start | May 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $641,317 |
| NIH project number | 5R01AG079224-02 |
| Project ID | NIH-11086773 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly those with the APOE4 allele, who are at higher risk for Alzheimer's disease.
✕Less likely to help
Patients without any APOE genetic variations or those who are not at risk for Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in the development of Alzheimer's disease, particularly focusing on how different genetic variations of the APOE gene affect inflammation and cognitive decline in older adults. The study aims to understand how neutrophil activation and lifespan can be targeted to potentially reduce the risk or progression of Alzheimer's disease. Additionally, it will explore the interactions between gut microbiota and the immune system, which may influence neuroinflammation and cognitive health. By examining these factors, the research seeks to uncover new therapeutic strategies tailored to individuals based on their genetic makeup.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments that reduce the risk of Alzheimer's disease and improve cognitive health in aging populations.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mc Laughlin Research Institute
Great Falls, United States Active
Researchers
- Principal investigator: Hensley-Mcbain, Tiffany — Mc Laughlin Research Institute
- Study coordinator: Hensley-Mcbain, Tiffany
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.