Exploring how genetic changes in blood cells affect heart disease
CORE 2: Genetic Engineering Core
This study is looking at how changing DNA in certain blood cells can help us learn more about heart diseases, with the hope that it will lead to better treatments for people with blood disorders and heart problems.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11012928 on NIH RePORTER |
What this research studies
This research focuses on using advanced genetic engineering techniques to modify DNA in blood-forming stem cells and animal models. By creating these modified cells, researchers aim to better understand the connection between blood cell formation and cardiovascular diseases, which are a major health concern. The project involves designing and optimizing genome editing strategies to test biological hypotheses in living organisms, ultimately aiming to uncover new insights into disease progression. Patients may benefit from the findings that could lead to improved treatments for blood disorders and heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders or those at risk for cardiovascular diseases.
Not a fit: Patients with conditions unrelated to blood cell formation or cardiovascular health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for cardiovascular diseases and blood disorders.
How similar studies have performed: Other research has shown promise in using genetic engineering to understand and treat blood-related diseases, indicating a strong potential for success in this area.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kleinstiver, Benjamin Peter — Massachusetts General Hospital
- Study coordinator: Kleinstiver, Benjamin Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.