Exploring how genetic changes affect immune response in brain tumors
3-D spatial approach to discover genomic effectors of immunosuppression during malignant transformation
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10880270
This study is looking at how changes in a specific gene might affect the immune system in patients with low-grade gliomas as they become more aggressive, with the goal of finding better ways to boost immune treatments for those fighting these tumors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10880270 on ClinicalTrials.gov |
What this research studies
This research investigates how mutations in a specific gene (IDH) influence the immune environment in low-grade gliomas as they transform into more aggressive tumors. By using a novel 3-dimensional approach, the study aims to analyze spatial changes in immune cell activity and genetic alterations during this transformation. The researchers will collect multiple samples from each tumor to understand how these changes impact the immune response, particularly focusing on T cells that are crucial for fighting cancer. This could lead to new insights into how to enhance immune therapies for patients with these tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with IDH-mutant low-grade gliomas who are experiencing malignant transformation.
Not a fit: Patients with non-IDH-mutant gliomas or those who are not undergoing malignant transformation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy strategies for patients with low-grade gliomas that transform into high-grade tumors.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in tumors, but this specific 3-D approach is relatively novel and untested.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COSTELLO, JOSEPH F — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: COSTELLO, JOSEPH F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.