Exploring how genes linked to COPD interact with each other
Identifying Protein-Protein Network Interactions between COPD Susceptibility Genes
This study is looking at how certain proteins linked to Chronic Obstructive Pulmonary Disease (COPD) work together, with the hope that understanding these connections will help improve treatments and care for people living with COPD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10764202 on NIH RePORTER |
What this research studies
This research investigates the interactions between proteins associated with genes that increase the risk of Chronic Obstructive Pulmonary Disease (COPD). By using advanced techniques like affinity purification and mass spectrometry, the study aims to identify how these proteins work together and how their interactions may contribute to the disease. The goal is to uncover new biological connections that could lead to better understanding and treatment of COPD-related issues such as cell death and inflammation. Patients may benefit from insights gained into the molecular mechanisms of COPD, potentially leading to targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to COPD or those diagnosed with the disease.
Not a fit: Patients without a genetic link to COPD or those with unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better target the underlying causes of COPD.
How similar studies have performed: Previous research has shown success in identifying protein interactions in other complex diseases, suggesting a promising approach for COPD.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Silverman, Edwin K — Brigham and Women's Hospital
- Study coordinator: Silverman, Edwin K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.