Exploring how genes interact with different environments to affect health traits
Understanding and using gene-by-context interactions in human complex trait genetics
This study is looking at how our genes and the environment work together to affect our health, aiming to create better tools that help predict the risk of complex diseases for everyone, no matter their background.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project ID | NIH-10900787 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence complex health traits, focusing on how genes interact with various environmental contexts. By analyzing data from genome-wide association studies (GWAS), the project aims to improve the accuracy of predictions related to complex diseases through the development of Polygenic Risk Scores (PRS). The study addresses the limitations of current genetic analyses, particularly the lack of diversity in ancestry representation, which affects the applicability of findings across different populations. Ultimately, the goal is to enhance personalized medicine by providing more accurate risk assessments for individuals based on their genetic makeup and environmental factors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with complex health traits or diseases, particularly those from diverse ancestral backgrounds.
Not a fit: Patients with purely monogenic disorders may not benefit from this research as it focuses on complex traits influenced by multiple genetic and environmental factors.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of disease risk and better-targeted treatments for patients.
How similar studies have performed: Previous research has shown promise in using genetic analyses to improve disease prediction, but this approach aims to address significant gaps in diversity and accuracy, making it a novel endeavor.
Where this research is happening
Clemson, United States
- Clemson University — Clemson, United States (Active)
Researchers
- Principal investigator: Morgante, Fabio — Clemson University
- Study coordinator: Morgante, Fabio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.