Exploring how genes interact to influence health and disease
Official title: Next generation massively multiplexed combinatorial genetic screens
Funded at University of California, San Diego · NIH-11013410 · Data updated 2026-11-12
This study is looking at how different genes work together and how that affects our health, using cutting-edge tools to help find new ways to treat diseases that come from these genetic interactions, which could ultimately benefit patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $678,814 |
| NIH project number | 5R01HG012351-03 |
| Project ID | NIH-11013410 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or those at risk for diseases influenced by complex gene interactions.
✕Less likely to help
Patients with conditions that are not primarily influenced by genetic factors may not receive benefit from this research.
What this research studies
This research investigates the complex interactions between genes and how these interactions affect cellular and organismal traits. By utilizing advanced techniques like CRISPR-Cas systems, the study aims to map these gene-gene relationships, which could reveal new insights into the genetic basis of human diseases. The approach involves creating combinatorial genetic screens that allow researchers to analyze multiple gene perturbations simultaneously, overcoming challenges in data analysis and library generation. Patients may benefit from the findings as they could lead to new therapeutic strategies targeting genetic interactions.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating genetic diseases by identifying new therapeutic targets.
How similar studies have gone: Previous research using combinatorial genetic screens has shown promise in mapping gene interactions, indicating that this approach has potential for success.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Mali, Prashant — University of California, San Diego
- Study coordinator: Mali, Prashant
Related research
Other NIH-funded projects on the same topics.
-
Improved MRI guidance for pediatric heart catheterization using autonomous multi-beat image synthesis
Aiming to make MRI-guided pediatric heart catheterizations safer and more reliable by using smart, multi-beat data fusion to produce clearer real-time MRI images.
-
Adapting a combination approach to reduce heavy drinking and boost HIV care and prevention among young men
A pilot project tests a proven program that helps young men cut down on heavy drinking and improves HIV treatment and prevention outcomes.
-
How specific anti-NMDAR1 antibodies in the blood may affect memory and brain protection
This research is exploring whether natural or abnormal anti-NMDAR1 antibodies in the blood influence memory, behavior, and brain protection in humans.
-
Screening and treatment of Chlamydia infection in pregnancy to help prevent preterm birth
This grant studies whether screening pregnant people for Chlamydia trachomatis and treating those who are positive can reduce the risk of preterm birth.
-
Pharmacometrics Core at UC San Diego
A pharmacometrics core is funded to support researchers in analyzing drug data to improve how medicines work for patients.
-
Milk Analytics Core for Precision Dairy Research
A core facility at UC San Diego will provide specialized milk analysis services to support research on dairy biology and human health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.