Exploring how genes interact to influence health and disease
Next generation massively multiplexed combinatorial genetic screens
This study is looking at how different genes work together and how that affects our health, using cutting-edge tools to help find new ways to treat diseases that come from these genetic interactions, which could ultimately benefit patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11013410 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between genes and how these interactions affect cellular and organismal traits. By utilizing advanced techniques like CRISPR-Cas systems, the study aims to map these gene-gene relationships, which could reveal new insights into the genetic basis of human diseases. The approach involves creating combinatorial genetic screens that allow researchers to analyze multiple gene perturbations simultaneously, overcoming challenges in data analysis and library generation. Patients may benefit from the findings as they could lead to new therapeutic strategies targeting genetic interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or those at risk for diseases influenced by complex gene interactions.
Not a fit: Patients with conditions that are not primarily influenced by genetic factors may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating genetic diseases by identifying new therapeutic targets.
How similar studies have performed: Previous research using combinatorial genetic screens has shown promise in mapping gene interactions, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Mali, Prashant — University of California, San Diego
- Study coordinator: Mali, Prashant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.