Exploring how gene regulatory networks evolve across different species
Leveraging multi-species single cell omic datasets to study the evolution of cell type-specific gene regulatory networks
This study is looking at how the systems that control gene activity in different cell types change over time in various species, using advanced technology to examine individual cells, which could help us understand how problems in these systems might lead to diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10923882 on NIH RePORTER |
What this research studies
This research investigates the evolution of gene regulatory networks (GRNs) that control gene expression in different cell types across various species. By utilizing advanced single-cell omic technologies like ATAC-seq, the project aims to profile genomic activity at an individual cell level, allowing for a deeper understanding of how these networks function and change over time. The study will develop new computational methods to analyze and compare these networks, addressing challenges in integrating data from multiple species. This could lead to insights into how disruptions in these networks contribute to diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases linked to disruptions in gene regulatory networks.
Not a fit: Patients with conditions unrelated to gene regulation or those not affected by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic diseases and lead to new therapeutic strategies.
How similar studies have performed: Other research has shown success in using single-cell omic technologies to study gene regulation, indicating a promising approach for this project.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Roy, Sushmita — University of Wisconsin-Madison
- Study coordinator: Roy, Sushmita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.