Exploring how gene regulation varies between humans and apes
Characterizing and Understanding Variation in Gene Regulatory Mechanisms Within and Between Species
This study is looking at how our genes work and change in humans and apes, especially how they react to different environments, to help us understand why people might respond differently to things like diseases or treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11132810 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms that control gene regulation in humans and non-human apes, focusing on how these mechanisms have evolved and how they respond to environmental factors. By analyzing genetic variants and their effects on gene expression, the research aims to uncover the underlying causes of individual differences in response to various exposures. The study utilizes induced pluripotent stem cells (iPSCs) from both species to explore these regulatory differences across various cell types, providing insights into complex traits and diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in genetic studies, particularly those with a family history of complex traits or diseases influenced by gene regulation.
Not a fit: Patients with conditions unrelated to genetic regulation or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors influencing health and disease, potentially leading to improved treatments and preventive strategies.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through comparative studies, indicating that this approach has the potential for significant insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Gilad, Yoav — University of Chicago
- Study coordinator: Gilad, Yoav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.