Exploring how gene expression in bacteria affects their behavior and population success
Multi-scale, model-driven exploration of sub-generational gene expression in bacteria: individual consequences, population benefits
This study looks at how differences in gene activity among bacteria can create a variety of behaviors that help the whole group thrive, especially when facing changes in their environment, using E. coli as a model to explore this teamwork.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10879030 on NIH RePORTER |
What this research studies
This research investigates how variations in gene expression among individual bacteria can lead to diverse behaviors within a population, ultimately benefiting the group as a whole. By focusing on sub-generational gene expression, the study aims to understand how certain genes and operons function together to enhance the population's ability to adapt to environmental changes. The approach combines computational modeling with experimental measurements, particularly using E. coli as a model organism. This work seeks to uncover the balance between individual bacterial fitness and collective population advantages.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by antibiotic-resistant bacteria, particularly those involving E. coli.
Not a fit: Patients with viral infections or those not affected by bacterial pathogens may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing bacterial populations, which may enhance the effectiveness of antibiotic treatments.
How similar studies have performed: Previous research has shown promising results in understanding bacterial behavior through gene expression studies, indicating that this approach has potential for significant insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Covert, Markus W — Stanford University
- Study coordinator: Covert, Markus W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.