Exploring how gene expression affects brain connectivity during development and adulthood
Association of gene expression and brain connectivity in human cerebral cortex development and adulthood
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10893517
This study is looking at how our genes affect the way different parts of the brain connect with each other as we grow up, which could help us understand more about conditions like autism.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10893517 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between gene expression patterns and brain connectivity in humans from childhood through adulthood. By analyzing neural MRI and transcriptome data, the study aims to create a detailed map of how genes influence the connections between different brain regions over time. This approach could help identify specific genes and connectivity patterns that are linked to neuropsychiatric disorders like autism spectrum disorder. The research will utilize advanced imaging techniques and computational tools to gather and analyze data across various developmental stages.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 12 years and older, particularly those diagnosed with autism spectrum disorder or related neuropsychiatric conditions.
Not a fit: Patients with neurodevelopmental disorders not related to autism spectrum disorder may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for neuropsychiatric disorders by identifying key genetic factors involved in brain connectivity.
How similar studies have performed: Previous research has shown promising results in linking gene expression to brain connectivity, suggesting that this approach could yield valuable insights into neuropsychiatric disorders.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, HAO — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: HUANG, HAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder