Exploring how GDF15 affects obesity and diabetes
Novel aspects of Gdf15 biology and function
This study is looking at how a protein called GDF15 might help manage weight and improve insulin sensitivity in people with obesity and type 2 diabetes, even without losing weight, to find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11046110 on NIH RePORTER |
What this research studies
This research investigates the role of Growth Differentiation Factor 15 (GDF15), a cytokine linked to obesity and type 2 diabetes, in regulating body weight and improving insulin sensitivity. The study aims to understand how GDF15 functions in the body, particularly its effects on glucose metabolism and energy expenditure, independent of weight loss. By using animal models, researchers will explore the mechanisms through which GDF15 may help mitigate the progression of these conditions, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from obesity or type 2 diabetes who may benefit from improved metabolic regulation.
Not a fit: Patients who do not have obesity or type 2 diabetes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and aid in weight management for patients with obesity and type 2 diabetes.
How similar studies have performed: Previous research has shown promising results with GDF15 in animal models, indicating potential for success in this novel approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Jurczak, Michael J. — University of Pittsburgh at Pittsburgh
- Study coordinator: Jurczak, Michael J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.