Exploring how g-Tocotrienol may prevent breast cancer after childbirth
Official title: Investigating the efficacy of g-Tocotrienol for the prevention of post-partum breast cancer
Funded at Icahn School of Medicine at Mount Sinai · NIH-11129248 · Data updated 2026-11-12
This study is looking at whether a dietary supplement called g-Tocotrienol can help prevent breast cancer after childbirth, especially for women who have babies later in life, by exploring how breastfeeding might protect against the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $605,314 |
| NIH project number | 1R01CA301372-01 |
| Project ID | NIH-11129248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have recently given birth, particularly those over the age of 30, who may be at increased risk for post-partum breast cancer.
✕Less likely to help
Patients who are not recent mothers or those who have not given birth may not benefit from this research.
What this research studies
This research investigates the potential of g-Tocotrienol, a dietary supplement, to prevent post-partum breast cancer, particularly in women who give birth later in life. The study utilizes mouse models to understand the mechanisms behind lactation's protective effects against breast cancer, focusing on how various factors like diet and pregnancy history influence outcomes. By examining the cellular processes involved in lactation and their relationship with breast cancer risk, the research aims to identify effective prevention strategies for at-risk women.
Why it matters
Potential benefit: If successful, this research could lead to new preventive measures for post-partum breast cancer, potentially reducing the incidence of this disease in women who give birth later in life.
How similar studies have gone: While the specific approach of using g-Tocotrienol in this context is novel, previous research has shown that dietary supplements can influence cancer risk, suggesting potential for success.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Germain, Doris a — Icahn School of Medicine at Mount Sinai
- Study coordinator: Germain, Doris a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.