Exploring how exercise hormone irisin may improve cognitive function in aging and Alzheimer's disease.
FNDC5/irisin as a Molecular Mediator of Exercise Benefits in Cognitive Function
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10993163
This study is looking at how a hormone called irisin, which is released when we exercise, might help improve thinking and memory in people with Alzheimer's disease by promoting the growth of new brain cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10993163 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a hormone called irisin, which is released during exercise, in enhancing cognitive function, particularly in individuals affected by Alzheimer's disease. The study aims to understand how irisin influences the growth of new brain cells in the hippocampus, a region critical for learning and memory. By using advanced molecular techniques and behavioral tests in mouse models, the researchers will explore the connection between physical activity and cognitive improvements. This could lead to new therapeutic strategies for age-related cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients with cognitive impairments not related to aging or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that harness the benefits of exercise to improve cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results regarding the cognitive benefits of exercise, making this research a continuation of established findings.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WRANN, CHRISTIANE D. — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: WRANN, CHRISTIANE D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia