Exploring how exercise and metabolism affect memory in aging and Alzheimer's disease
Investigating the interface of epigenetics and metabolism underlying memory formation in the adult, aging, and AD brain
This study is looking at how exercise can help improve memory and brain health in older adults, especially those 65 and up, and it hopes to find ways to keep your mind sharp even if you can't be active all the time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11049052 on NIH RePORTER |
What this research studies
This research investigates the relationship between exercise, metabolism, and memory formation in adults, particularly focusing on those aged 65 and older. It aims to understand how physical activity can influence brain health and cognitive function, especially in the context of aging and Alzheimer's disease. The study will explore the role of epigenetic mechanisms in creating a 'molecular memory' that helps maintain cognitive abilities despite periods of inactivity. By examining how exercise impacts brain-derived neurotrophic factor (BDNF) levels, the research seeks to identify potential interventions to enhance memory and learning in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 65 and older, especially those experiencing cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients under the age of 65 or those with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline and improving memory in older adults, particularly those at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the benefits of exercise on cognitive function, suggesting that this approach may yield significant insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Wood, Marcelo Andres — University of California-Irvine
- Study coordinator: Wood, Marcelo Andres
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.