Exploring how exercise affects Alzheimer's disease in older adults
Official title: Precision Medicine in Alzheimer’s Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses
Funded at Arizona State University-Tempe Campus · NIH-11113409 · Data updated 2026-11-12
This study is looking at how a 6-month exercise program can help improve both physical and mental health for older adults with Alzheimer's, especially focusing on Latinx and non-Hispanic White communities, while also exploring their thoughts about exercise and any challenges they face in joining such programs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $34,960 |
| NIH project number | 3R01AG076566-02S1 |
| Project ID | NIH-11113409 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above, particularly those diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients who are younger than 65 or do not have a diagnosis of Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the impact of a 6-month aerobic exercise program on physical and cognitive health in older adults with Alzheimer's disease, focusing on both Latinx and non-Hispanic White participants. The study aims to understand the attitudes and beliefs about exercise within these communities through surveys and interviews. By comparing responses from different demographic groups, the research seeks to identify barriers to participation in exercise programs and optimize interventions for better health outcomes. The study utilizes a mixed-methods approach to gather comprehensive data on the effects of exercise on Alzheimer's-related biomarkers.
Why it matters
Potential benefit: If successful, this research could lead to more effective exercise interventions tailored to improve health outcomes for older adults with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in using aerobic exercise as a treatment for Alzheimer's disease, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Yu, Fang — Arizona State University-Tempe Campus
- Study coordinator: Yu, Fang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.