Exploring how epigenetics and non-coding RNA affect leukemia
Integration of epigenetic and non-coding RNA mechanism in leukemia
['FUNDING_R37'] · THOMAS JEFFERSON UNIVERSITY · NIH-10917025
This study is looking at how certain changes in our genes and tiny RNA molecules might affect the development of acute myeloid leukemia (AML) and how the disease responds to treatment, with the hope that this research will help create better, more personalized therapies for patients like you.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10917025 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of epigenetic modifications and non-coding RNA in the development and progression of leukemia, particularly acute myeloid leukemia (AML). By utilizing advanced techniques such as CRISPR, the study aims to understand how these molecular mechanisms contribute to the disease and its resistance to treatment. Patients may benefit from insights gained that could lead to more effective therapies tailored to their specific genetic and epigenetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia, both children and adults.
Not a fit: Patients with leukemia types other than acute myeloid leukemia may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve outcomes for leukemia patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetics in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MEYER, SARA E — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: MEYER, SARA E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.