Exploring how epigenetic molecules can help treat gum disease
Official title: Potentials of Epigenetic Molecules in Attenuating the Phenotypes of Periodontitis
Funded at Tufts University Boston · NIH-10868743 · Data updated 2026-11-12
This study is looking at new ways to help treat gum disease by using special molecules that could help your body heal and improve your oral health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $646,651 |
| NIH project number | 5R01DE032006-02 |
| Project ID | NIH-10868743 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over the age of 21 who are experiencing symptoms of periodontitis.
✕Less likely to help
Patients with mild gum disease or those who do not have periodontitis may not receive significant benefits from this research.
What this research studies
This research investigates the potential of epigenetic molecules to improve treatments for periodontitis, a common gum disease affecting many adults. The team is exploring innovative therapies that target the underlying causes of the disease, such as inflammation and bone loss, using advanced techniques like gene therapy and synthetic inhibitors. By focusing on specific molecules that regulate gene expression, the research aims to stimulate the body's natural ability to regenerate lost tissue and improve overall oral health.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for periodontitis, reducing inflammation and promoting bone regeneration.
How similar studies have gone: Other research has shown promise in using epigenetic approaches for various diseases, suggesting potential success for this novel application in periodontitis.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: Chen, Jake Jinkun — Tufts University Boston
- Study coordinator: Chen, Jake Jinkun
Related research
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Grade C Periodontitis in Young People: Genetic Clues to a Severe, Early Condition
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Diabetes-Driven Changes in Dendritic Cells and T Cells in Gum Disease
This project studies how poorly controlled diabetes alters immune cells in periodontitis to worsen gum disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.