Exploring how environmental toxins affect heart and ovarian health
Identifying critical mediators of ovarian and cardiovascular health
['FUNDING_CAREER'] · BROWN UNIVERSITY · NIH-11070319
This study is looking at how a harmful chemical called TCDD might affect young people's heart and reproductive health, with the goal of finding better ways to treat heart disease and infertility.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-11070319 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of environmental contaminants, specifically 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), on both ovarian and cardiovascular health. It aims to understand how exposure to TCDD during youth can lead to heart disease and infertility by examining the interactions between these two systems. The study will utilize advanced techniques like single-cell sequencing to identify the cellular and molecular effects of TCDD on the heart and ovary. By uncovering these mechanisms, the research seeks to provide insights that could lead to better treatments for heart disease and infertility.
Who could benefit from this research
Good fit: Ideal candidates for this research include women over 21 years old who have experienced infertility or heart health issues potentially related to environmental toxin exposure.
Not a fit: Patients who do not have a history of exposure to environmental toxins or those without heart or ovarian health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals suffering from heart disease and infertility linked to environmental toxin exposure.
How similar studies have performed: Previous research has shown that environmental toxins can adversely affect health, but this study's focus on the interplay between ovarian and cardiovascular health is relatively novel.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOSSACK, MICHELLE — BROWN UNIVERSITY
- Study coordinator: KOSSACK, MICHELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.