Exploring how environmental factors and genetics affect brain changes in Alzheimer's disease.
Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.
This study is looking at how our environment and genes might affect brain changes linked to Alzheimer's and similar diseases, especially focusing on diverse groups of people, to find new ways to help treat these conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-10657846 on NIH RePORTER |
What this research studies
This research investigates the relationship between environmental exposures and genetic factors in influencing brain changes associated with Alzheimer's disease and related disorders. By analyzing data from diverse cohorts, including underrepresented racial and ethnic groups, the study aims to identify molecular changes in the brain that may contribute to the progression of these diseases. The research utilizes advanced techniques such as multiomics profiling, which includes genetic, transcriptomic, and epigenomic data, to provide a comprehensive understanding of the underlying mechanisms. Participants' brain samples will be compared across different disease stages to determine potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from diverse racial and ethnic backgrounds, particularly those with a family history of Alzheimer's disease or related disorders.
Not a fit: Patients who do not have a diagnosis of Alzheimer's disease or related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease and related disorders, particularly for diverse populations.
How similar studies have performed: Previous research has shown promise in using multiomics approaches to understand complex diseases, indicating that this method could yield valuable insights.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Ertekin-Taner, Nilufer — Mayo Clinic Jacksonville
- Study coordinator: Ertekin-Taner, Nilufer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.