Exploring how environmental cues influence nicotine use and addiction

Understanding and mitigating exacerbated nicotine use resulting from Pavlovianinteroceptive conditioning

NIH-funded research University of Nebraska Lincoln · NIH-11078280

This study looks at how things around us and how we feel when using nicotine can make some people more likely to become addicted, especially focusing on differences between men and women, to help understand and reduce nicotine dependence.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Nebraska Lincoln NIH-funded
Lab location1 site (Lincoln, United States)
Project IDNIH-11078280 on NIH RePORTER

What this research studies

This research investigates how environmental factors and internal sensations associated with nicotine use can lead to increased addiction and misuse. It focuses on understanding the conditioning processes that make certain stimuli trigger cravings for nicotine, particularly in different sexes. By examining these associations, the study aims to identify why some individuals become more dependent on nicotine and how this can be mitigated. The research employs a combination of behavioral assessments and conditioning experiments to gather data on nicotine-seeking behavior.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who use nicotine products, including smokers and vapers, particularly those who may experience challenges in quitting.

Not a fit: Patients who do not use nicotine products or have no interest in quitting may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective strategies for preventing and treating nicotine addiction.

How similar studies have performed: Previous research has shown that conditioning processes significantly influence substance use behaviors, suggesting that this approach could yield valuable insights.

Where this research is happening

Lincoln, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Cancers
Last reviewed 2026-06-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.