Exploring how environmental contaminants interact with important receptors in the body
Official title: Investigating environmental contaminant interactions on the GPCRome: an unexplored landscape of activity
Funded at University of Iowa · NIH-11056783 · Data updated 2026-11-12
This study is looking at how certain harmful chemicals in our environment, like PFAS, affect important receptors in our bodies that help regulate many functions, so we can better understand the risks they pose to our health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | March 18, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $233,250 |
| NIH project number | 5R21ES036329-02 |
| Project ID | NIH-11056783 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to environmental contaminants or are concerned about the health effects of such exposures.
✕Less likely to help
Patients who have no history of exposure to environmental contaminants may not benefit from this research.
What this research studies
This research investigates how various environmental contaminants affect G protein-coupled receptors (GPCRs), which play a crucial role in many physiological processes. By using advanced screening techniques, the study aims to identify new interactions between contaminants and GPCRs, shedding light on the mechanisms behind their harmful effects. The research will focus on specific contaminants, including per- and polyfluoroalkyl substances (PFAS), to understand their impact on human health. This could lead to better understanding and management of the risks posed by these environmental toxins.
Why it matters
Potential benefit: If successful, this research could lead to improved safety regulations and health guidelines regarding exposure to environmental contaminants.
How similar studies have gone: While research on GPCR interactions with contaminants is limited, preliminary studies have shown promising results, indicating potential for success in this area.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Roman, David L. — University of Iowa
- Study coordinator: Roman, David L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.