Exploring how dying cells affect tissue healing and regeneration
Understanding Necrosis-Induced Tissue Regeneration
This study is looking at how dying cells can affect the healing of nearby tissues after injuries or illnesses, like burns or heart attacks, to find new ways to help people recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10890620 on NIH RePORTER |
What this research studies
This research investigates the role of necrosis, a form of cell death, in influencing the behavior of surrounding tissues during recovery from injuries or diseases. By examining the signals released from necrotic cells, the study aims to uncover how these signals can affect the survival and proliferation of neighboring cells. The research will utilize various methodologies to analyze the impact of necrotic wounds on tissue regeneration, potentially leading to new therapeutic strategies for improving healing outcomes. The findings could provide insights into conditions such as burns, strokes, and heart attacks.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 who have experienced traumatic injuries, such as burns or ischemic events.
Not a fit: Patients with conditions unrelated to necrosis or those who are not experiencing tissue regeneration challenges may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that enhance tissue healing and regeneration after injuries.
How similar studies have performed: While the role of apoptotic cell death in tissue repair has been well-studied, the specific impact of necrosis on tissue behavior is less understood, making this research a novel exploration.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Harris, Robin — Arizona State University-Tempe Campus
- Study coordinator: Harris, Robin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.