Exploring how drugs and the bone marrow environment affect acute myeloid leukemia.
Investigating the Microenvironmental Dysregulation and Polypharmacy Impact during Acute Myeloid Leukemia in an in vitro model of the human bone marrow and in vivo models.
This study is looking at how different medications and the environment around leukemia cells affect the success of chemotherapy for people with acute myeloid leukemia (AML), with the hope of finding better ways to help patients respond to treatment and live longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10987768 on NIH RePORTER |
What this research studies
This research investigates the effects of multiple medications and the bone marrow environment on acute myeloid leukemia (AML). Using advanced 3D modeling techniques, the study aims to understand how these factors influence the effectiveness of standard chemotherapy treatments. By examining both in vitro (lab-based) and in vivo (live model) systems, the research seeks to uncover the interactions between AML cells and their surrounding environment, which may lead to better treatment strategies. Patients may benefit from insights that could improve their response to chemotherapy and overall survival rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with acute myeloid leukemia.
Not a fit: Patients with other types of leukemia or those who are not currently undergoing treatment for AML may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for patients with acute myeloid leukemia, potentially increasing survival rates.
How similar studies have performed: Previous studies have shown promising results in understanding the role of the bone marrow microenvironment in leukemia, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Sharipol, Azmeer — University of Rochester
- Study coordinator: Sharipol, Azmeer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.