Exploring how Down's Syndrome affects placental development
Official title: Defining the link between trisomy 21 and placentation defects
Funded at University of Colorado · NIH-10999075 · Data updated 2026-11-12
This study is looking at how Down's Syndrome might affect the placenta during pregnancy, which can lead to complications, and it aims to find out what goes wrong in the placental cells of people with Down's Syndrome compared to those without it, hoping to discover ways to improve pregnancy outcomes for families affected by this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $76,408 |
| NIH project number | 1F32HD116568-01 |
| Project ID | NIH-10999075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant individuals diagnosed with Down's Syndrome or those carrying a fetus with this condition.
✕Less likely to help
Patients who do not have Down's Syndrome or are not pregnant may not benefit from this research.
What this research studies
This research investigates the relationship between Down's Syndrome (trisomy 21) and placentation defects that can lead to serious pregnancy complications. By using advanced techniques like CRISPR/Cas9 and RNA sequencing, the study aims to understand how placental cells in individuals with Down's Syndrome fail to develop properly. The research will compare these cells with those from individuals without the condition to identify key differences and potential therapeutic targets. Ultimately, the goal is to uncover mechanisms that could improve pregnancy outcomes for those affected by Down's Syndrome.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for pregnancies affected by Down's Syndrome, potentially reducing risks of stillbirth and growth restrictions.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that understanding placental biology can lead to significant advancements in managing pregnancy complications.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Logsdon, Deirdre — University of Colorado
- Study coordinator: Logsdon, Deirdre
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.