Exploring how DNA topoisomerases affect cancer biology
Understanding and exploiting DNA topoisomerases in cancer biology
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10900669
This study is looking at how certain enzymes that help manage DNA can affect cancer and how they interact with cancer treatments, with the hope of finding better ways to fight the disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10900669 on ClinicalTrials.gov |
What this research studies
This research investigates the role of type II DNA topoisomerases, which are crucial enzymes that manage DNA structure and integrity. By examining how these enzymes function and their interactions with cancer drugs, the research aims to uncover new insights into cancer development and treatment. The study employs a variety of advanced techniques, including biochemical assays and computational modeling, to understand how these enzymes can both protect and damage genetic material. Ultimately, the goal is to improve cancer therapies by targeting these enzymes more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with various types of cancer who may benefit from novel therapeutic approaches targeting DNA topoisomerases.
Not a fit: Patients with non-cancerous conditions or those whose cancer is not influenced by DNA topoisomerases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by improving our understanding of how to target DNA topoisomerases.
How similar studies have performed: Previous research has shown promising results in targeting DNA topoisomerases for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERGER, JAMES M. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: BERGER, JAMES M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents, Cancer Biology, Cancer Cause, Cancer Drug, Cancer Etiology