Exploring how DNA repair affects breast cancer outcomes in African American women
Understanding the role of DNA damage repair in racial disparities of triple-negative breast cancer outcomes
This study is looking into why African American women with triple-negative breast cancer tend to have worse outcomes than European American women, focusing on how their bodies repair DNA damage and how that affects their response to chemotherapy, with the hope of finding better treatment options for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11031388 on NIH RePORTER |
What this research studies
This research investigates the reasons behind the poorer outcomes of triple-negative breast cancer (TNBC) in African American women compared to European American women. It focuses on the molecular mechanisms of DNA damage repair, particularly how different repair pathways may influence tumor response to chemotherapy. By analyzing the expression of specific proteins involved in DNA repair, the study aims to uncover why African American patients experience higher mortality rates from TNBC. The findings could lead to more effective treatment strategies tailored to the unique biological characteristics of TNBC in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American women diagnosed with triple-negative breast cancer.
Not a fit: Patients with other subtypes of breast cancer or those not of African American descent may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for African American women with triple-negative breast cancer.
How similar studies have performed: Previous research has indicated disparities in cancer outcomes based on genetic and biological factors, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Shao, Jieya — Washington University
- Study coordinator: Shao, Jieya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.