Exploring how DNA loops can regulate genes
Fundamental and applied studies of nucleic acids
['FUNDING_OTHER'] · MAYO CLINIC ROCHESTER · NIH-11014358
This study is exploring how tiny loops in DNA can affect how genes work, and it's for anyone interested in how this research could lead to better gene therapies and treatments for health conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11014358 on ClinicalTrials.gov |
What this research studies
This research investigates the fundamental and applied aspects of nucleic acids, focusing on how DNA looping can influence gene regulation. The team will conduct experiments both in laboratory settings and in living E. coli cells to understand how small DNA loops form and how they can be manipulated using specially designed proteins. By creating artificial gene regulatory loops, the research aims to enhance our understanding of gene expression and its applications in synthetic biology. Patients may benefit from advancements in gene therapy and targeted treatments stemming from these findings.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or those interested in cutting-edge gene therapy techniques.
Not a fit: Patients with conditions unrelated to genetic regulation or those not seeking experimental therapies may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative gene therapies that improve treatment options for various genetic conditions.
How similar studies have performed: Previous research in synthetic biology has shown promise in manipulating gene regulation through DNA looping, indicating a potential for success in this approach.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAHER, LOUIS JAMES — MAYO CLINIC ROCHESTER
- Study coordinator: MAHER, LOUIS JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.