Exploring how DNA damage affects cell health and stability
Understanding the mechanistic role of genome stability pathways in regulating cell homeostasis
This study is looking at how our cells protect their DNA and fix any damage, which is really important for keeping us healthy and preventing diseases like cancer, and it's for anyone interested in understanding how our bodies work to stay safe from these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11031370 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells maintain their genomic integrity and respond to DNA damage, which is crucial for preventing diseases like cancer and neurological disorders. The study focuses on understanding how different pathways involved in genome stability operate in both dividing and non-dividing cells. By employing advanced techniques such as genome-wide sequencing and super-resolution microscopy, the research aims to uncover the interactions between DNA damage responses and cellular growth signals. This knowledge could lead to improved strategies for cancer treatment and other related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to genomic instability, such as certain cancers or neurological disorders.
Not a fit: Patients with stable genomic integrity and no history of DNA damage-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for cancer and other diseases linked to DNA damage.
How similar studies have performed: Previous research has shown promising results in understanding DNA damage responses and their implications for cancer therapy, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Huang, Tony Tung — New York University School of Medicine
- Study coordinator: Huang, Tony Tung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.