Exploring how disrupted sleep patterns affect multiple sclerosis progression
Understanding role of circadian disruption in pathogenesis of MS
This study is looking at how changes in sleep patterns might affect the healing of nerves in people with multiple sclerosis, and it aims to find new ways to help improve their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11034101 on NIH RePORTER |
What this research studies
This research investigates the impact of circadian rhythm disruption on the progression of multiple sclerosis (MS) and its effects on remyelination, which is crucial for nerve repair. The study aims to understand the mechanisms by which irregular sleep patterns may contribute to the failure of remyelination in MS patients. By examining genetic factors and biological processes in both animal models and human samples, the research seeks to identify new therapeutic strategies to improve patient outcomes. Patients may be involved in assessments of their sleep patterns and genetic predispositions related to MS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who experience sleep disturbances and fatigue.
Not a fit: Patients with MS who do not experience sleep issues or those with advanced disease stages may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve sleep and reduce fatigue in MS patients, enhancing their quality of life.
How similar studies have performed: Previous research has indicated that circadian rhythm disruptions can negatively impact neurological conditions, suggesting potential for success in this area.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Dutta, Ranjan — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dutta, Ranjan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.