Exploring how different types of histone proteins affect aging in cells
Official title: Interrogating the roles of canonical versus variant histone H3 in genome function during aging
Funded at Univ of North Carolina Chapel Hill · NIH-10831402 · Data updated 2026-11-12
This study is looking at how two types of proteins in our cells, called histones, affect how our cells age, using fruit flies to help us understand what happens as cells get older and how it might relate to our own aging.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | May 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $40,496 |
| NIH project number | 5F31AG079632-02 |
| Project ID | NIH-10831402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those with age-related cellular conditions.
✕Less likely to help
Patients with acute conditions unrelated to aging or cellular senescence may not benefit from this research.
What this research studies
This research investigates the roles of two types of histone proteins, canonical and variant histone H3, in the aging process of cells. By examining how these histones influence the structure of chromatin and gene expression, the study aims to understand the mechanisms behind cellular aging. The research utilizes Drosophila (fruit flies) as a model organism to explore how the regulation of these histones changes with age and affects lifespan. The findings could provide insights into the fundamental processes of aging at the cellular level.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy aging and potentially extending lifespan by targeting histone regulation.
How similar studies have gone: Previous research has shown that understanding histone regulation can impact aging processes, suggesting that this approach has potential for success.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Mcpherson, Jeanne-Marie — Univ of North Carolina Chapel Hill
- Study coordinator: Mcpherson, Jeanne-Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.