Exploring how different types of histone proteins affect aging in cells
Interrogating the roles of canonical versus variant histone H3 in genome function during aging
['FUNDING_FELLOWSHIP'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10831402
This study is looking at how two types of proteins in our cells, called histones, affect how our cells age, using fruit flies to help us understand what happens as cells get older and how it might relate to our own aging.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10831402 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of two types of histone proteins, canonical and variant histone H3, in the aging process of cells. By examining how these histones influence the structure of chromatin and gene expression, the study aims to understand the mechanisms behind cellular aging. The research utilizes Drosophila (fruit flies) as a model organism to explore how the regulation of these histones changes with age and affects lifespan. The findings could provide insights into the fundamental processes of aging at the cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those with age-related cellular conditions.
Not a fit: Patients with acute conditions unrelated to aging or cellular senescence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy aging and potentially extending lifespan by targeting histone regulation.
How similar studies have performed: Previous research has shown that understanding histone regulation can impact aging processes, suggesting that this approach has potential for success.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCPHERSON, JEANNE-MARIE — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: MCPHERSON, JEANNE-MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.