Exploring how different mutations in the p53 gene affect cancer development
Understanding the divergent functions of mutant p53
['FUNDING_FELLOWSHIP'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10880363
This study is looking at how certain changes in the p53 gene, especially the C132Y mutation, affect cancer growth and spread, so that patients can better understand how their specific gene changes might influence their treatment and recovery.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10880363 on ClinicalTrials.gov |
What this research studies
This research investigates the various functions of mutant p53, a critical tumor suppressor gene commonly altered in cancer. The study focuses on understanding how specific mutations, particularly the C132Y variant, influence tumor behavior and progression. By using both laboratory techniques and animal models, researchers aim to uncover the mechanisms by which these mutations alter cellular processes and contribute to cancer metastasis. Patients may benefit from insights gained into how their specific p53 mutations could affect their cancer treatment and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients with identified mutations in the TP53 gene.
Not a fit: Patients without TP53 mutations or those with cancers unrelated to p53 alterations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized cancer therapies based on the specific mutations present in a patient's tumor.
How similar studies have performed: Previous research has shown that understanding specific mutations in cancer genes can lead to significant advancements in targeted therapies, suggesting a promising avenue for this investigation.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KENNEDY, MARGARET — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: KENNEDY, MARGARET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.