Exploring how different forms of α-synuclein fibrils affect brain diseases
Investigating the interplay between polymorphic α-syn fibril conformation and cell-dependent pathology
['FUNDING_R21'] · DREXEL UNIVERSITY · NIH-10951926
This study is looking at how different types of a protein called α-synuclein might affect brain cells in conditions like Lewy body dementia, Parkinson's disease, and multiple system atrophy, using special technology to mimic a real brain environment, so we can better understand how these diseases progress.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DREXEL UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10951926 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between various forms of α-synuclein fibrils and their role in diseases like Lewy body dementia, Parkinson's disease, and multiple system atrophy. By using advanced techniques such as human organ-on-a-chip technology, the study aims to understand how these fibrils interact with different cell types in the brain. The research will produce and analyze different α-synuclein fibril structures to see how they contribute to disease progression in a realistic brain environment. This approach could help clarify the mechanisms behind these neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lewy body dementia, Parkinson's disease, or multiple system atrophy.
Not a fit: Patients with other neurodegenerative diseases not related to synucleinopathies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for patients with synucleinopathies.
How similar studies have performed: Previous research has shown promising results in understanding amyloid fibrils in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- DREXEL UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, MYUNGWOON — DREXEL UNIVERSITY
- Study coordinator: LEE, MYUNGWOON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.