Exploring how different chromatin states affect gene regulation
Official title: Understanding How Distinct Heterochromatin States Control Pioneer Factor Binding
Funded at University of Southern California · NIH-10998751 · Data updated 2026-11-12
This study is looking at how certain proteins help control gene activity by interacting with a special part of our DNA called heterochromatin, which could help us understand how genes work properly during growth and in different types of cells, and it might also shed light on some developmental disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32GM156052-01 |
| Project ID | NIH-10998751 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with developmental disorders or those interested in the mechanisms of gene regulation during development.
✕Less likely to help
Patients with fully developed and stable gene expression profiles, without any developmental disorders, may not benefit from this research.
What this research studies
This research investigates the role of heterochromatin in regulating gene expression, particularly focusing on how certain proteins, known as pioneer factors, can bind to and modify these chromatin states. By examining the mechanisms that control the binding of these factors, the study aims to understand how proper gene regulation is maintained during development and in adult tissues. The research employs advanced techniques like ATAC sequencing and ChIP sequencing to analyze chromatin accessibility and transcription factor binding in various cell types. This could provide insights into developmental disorders and cell differentiation processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating developmental disorders by enhancing our understanding of gene regulation.
How similar studies have gone: Previous research has shown promising results in understanding chromatin dynamics and gene regulation, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Lowe, Matthew Gregory — University of Southern California
- Study coordinator: Lowe, Matthew Gregory
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.