NIH-funded research R01 grant

Exploring how dietary glutamine can help prevent and treat melanoma

Official title: Using dietary glutamine supplementation for melanoma prevention and targeted therapy

Funded at University of California-Irvine · NIH-10881802 · Data updated 2026-11-12

This study is looking at how adding more glutamine to your diet might help slow down melanoma, a type of skin cancer, and make cancer treatments work better, so patients can learn how their diet could improve their treatment results.

More Melanoma research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California-Irvine
NIH-funded
Lab location1 site (Irvine, United States)
Project startJuly 1, 2021
Project endJune 30, 2026
Funding year2024
Award (this year)$403,742
NIH project number5R01CA244360-04
Project IDNIH-10881802 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are melanoma patients who are looking for complementary approaches to enhance their treatment outcomes.

Less likely to help

Patients with melanoma who are not open to dietary changes or those with specific dietary restrictions may not benefit from this research.

What this research studies

This research investigates the effects of dietary glutamine supplementation on melanoma, a type of skin cancer. It aims to understand how increasing glutamine levels in the diet can inhibit tumor growth and enhance the effectiveness of cancer treatments. By analyzing tumor responses in patient-derived models, the study seeks to provide molecular evidence that nutritional interventions can play a crucial role in cancer therapy. Patients may benefit from a better understanding of how diet can influence their cancer treatment outcomes.

Why it matters

Potential benefit: If successful, this research could lead to new dietary recommendations that improve treatment responses and prevent melanoma progression.

How similar studies have gone: Previous research has shown promising results with dietary interventions in cancer treatment, suggesting that this approach may be effective.

Where this research is happening

  • University of California-Irvine
    Irvine, United States
    Active

Researchers

  • Principal investigator: Kong, Mei — University of California-Irvine
  • Study coordinator: Kong, Mei

Related research

Other NIH-funded projects on the same topics.

  • Dietary glutamine to prevent and treat melanoma

    Researchers are looking at whether adding glutamine to the diet can slow melanoma growth and help treatments work better for people with melanoma.

    NIH research University of California-Irvine · Irvine, United States · NIH-11113916

  • Targeting a new protein to improve melanoma treatment

    This study is looking at a new way to make melanoma treatments work better by focusing on a protein called eEF-2K, and it aims to help boost your immune system to fight the cancer more effectively, so patients might have the chance to try out this exciting new therapy in clinical trials.

    NIH research University of Kentucky · Lexington, United States · NIH-11060916

  • Identifying metabolic markers to track melanoma treatment response

    This study is looking at ways to use non-invasive imaging to help patients with metastatic melanoma, especially those with a specific BRAF gene mutation, by tracking how well their treatments are working and spotting any resistance to those treatments earlier than usual.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-10795952

  • Integrative histo-genomic analysis to guide cancer risk and targeted therapies with interpretable AI

    Researchers are developing an advanced AI-powered approach to map genetic and cellular patterns across breast and cervical cancers to help tailor treatments.

    NIH research Tuskegee University · Tuskegee Institute, United States · NIH-11621787

  • Targeted therapy for AML using DHODH inhibitors to boost differentiation and immune response

    Aims to help adults with acute myeloid leukemia by using a special drug approach that makes cancer cells act more like normal blood cells and supports the immune system.

    NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11611081

  • Melanoma vaccine built from tiny spherical nucleic acids

    A new kind of cancer vaccine using tiny spherical nucleic acids to help the immune system fight advanced melanoma.

    NIH research Northwestern University · Chicago, United States · NIH-11600597

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.