Exploring how diet and gut bacteria affect immune cells in the small intestine
Official title: Understanding diet-microbiota interactions in small intestine eosinophil tissue residency during homeostasis and eosinophilic granulomatosis with polyangiitis (EGPA)
Funded at Yale University · NIH-10865312 · Data updated 2026-11-12
This study is looking at how what we eat affects the good bacteria in our gut and how that, in turn, influences certain immune cells in the small intestine, which could help people with eosinophilic granulomatosis with polyangiitis (EGPA) understand how diet might improve their condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $173,556 |
| NIH project number | 1K08AR084069-01 |
| Project ID | NIH-10865312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with eosinophilic granulomatosis with polyangiitis or related inflammatory conditions.
✕Less likely to help
Patients without eosinophilic conditions or those not experiencing gastrointestinal symptoms may not benefit from this research.
What this research studies
This research investigates the interactions between dietary components and gut microbiota, focusing on their effects on eosinophil cells in the small intestine. By using a mouse model, the study aims to understand how these interactions influence immune responses during both normal conditions and in the context of eosinophilic granulomatosis with polyangiitis (EGPA). Patients may benefit from insights gained about how diet and gut health can impact inflammatory diseases, potentially leading to new dietary recommendations or treatments. The research is conducted by a physician scientist with expertise in immunology and rheumatology, supported by a prominent advisory committee.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary strategies for managing inflammatory diseases like EGPA.
How similar studies have gone: Previous research has shown promising results in understanding the role of diet and microbiota in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Korn, Lisa Lenore — Yale University
- Study coordinator: Korn, Lisa Lenore
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.