Exploring how deep brain stimulation affects brain networks in Parkinson's disease
Cortical Network Modulation by Subthalamic Nucleus Deep Brain Stimulation
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10687048
This study is looking at how deep brain stimulation helps people with Parkinson's disease by using a special imaging technique to see how it affects their movement and mood, all while keeping the process safe and comfortable for those with DBS implants.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10687048 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of deep brain stimulation (DBS) on the subthalamic nucleus in patients with Parkinson's disease. Using a novel imaging technique called high-density diffuse optical tomography (HD-DOT), the study aims to map brain activity and connectivity in real-time, providing insights into how DBS influences both motor functions and mood. The approach is designed to be safe and comfortable for patients with DBS implants, avoiding the limitations of traditional imaging methods. By understanding the brain's network responses to DBS, researchers hope to improve treatment outcomes for Parkinson's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are receiving deep brain stimulation treatment.
Not a fit: Patients who do not have Parkinson's disease or those who are not candidates for deep brain stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to enhanced deep brain stimulation techniques that minimize cognitive and mood side effects while maximizing motor benefits for Parkinson's patients.
How similar studies have performed: Other research has shown promising results using advanced imaging techniques to study brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HERSHEY, TAMARA G — WASHINGTON UNIVERSITY
- Study coordinator: HERSHEY, TAMARA G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.