Exploring how COVID-19 affects kidney health through viral infection and inflammation
Understanding the interplay between local viral infection and local inflammation in COVID-19 kidney injury
This study is looking at how COVID-19 affects the kidneys, especially in patients who have kidney problems, by checking for the virus in their urine and kidney tissues to help find better ways to treat kidney damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10671045 on NIH RePORTER |
What this research studies
This research investigates the relationship between local viral infection and inflammation in the kidneys of patients with COVID-19, particularly focusing on those who experience acute kidney injury (AKI). The study aims to analyze the presence of SARS-CoV-2 viral particles in kidney tissues and urine, as well as the genetic mutations of the virus that may occur during infection. By examining these factors, researchers hope to better understand the mechanisms behind kidney damage in COVID-19 patients and identify potential therapeutic targets. Patients with severe COVID-19 and AKI may provide urine samples for analysis, contributing to the understanding of this serious complication.
Who could benefit from this research
Good fit: Ideal candidates for participation include patients hospitalized with severe COVID-19 who are experiencing or at risk of acute kidney injury.
Not a fit: Patients with mild COVID-19 who do not experience kidney complications are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for kidney injury in COVID-19 patients.
How similar studies have performed: Previous research has indicated a connection between viral infections and kidney injury, suggesting that this approach may yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Blasi, Maria — Duke University
- Study coordinator: Blasi, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.