Exploring how COVID-19 affects blood sugar regulation through pancreatic cells
Investigating the link between pericyte dysfunction and loss of glucose homeostasis in COVID-19
This study is looking at how COVID-19 might affect blood sugar control by exploring how the virus interacts with special cells in the pancreas, which could help explain why some people develop diabetes after getting sick.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11088144 on NIH RePORTER |
What this research studies
This research investigates the impact of COVID-19 on glucose homeostasis by examining the role of pericytes, which are specialized cells in the pancreas. The study aims to understand how SARS-CoV-2 may infect these cells and disrupt their function, potentially leading to diabetes and other pancreatic issues. By analyzing the interaction between the virus and pericytes, researchers hope to uncover new insights into the mechanisms behind glucose intolerance in COVID-19 patients. This could involve laboratory experiments and patient data to establish a clearer link between the virus and pancreatic dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have had COVID-19 and are experiencing issues with blood sugar regulation or have a history of pancreatic diseases.
Not a fit: Patients who have not been infected with COVID-19 or do not have any pancreatic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing blood sugar levels in COVID-19 patients and those with related pancreatic conditions.
How similar studies have performed: While the specific focus on pericytes and COVID-19 is novel, there have been other studies indicating the virus's impact on the vascular system and its potential link to diabetes.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Almaca, Joana — University of Miami School of Medicine
- Study coordinator: Almaca, Joana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.