Exploring how colon cancer cells use iron for growth
Understanding the mechanisms of iron addiction in colon cancer
This study is looking at how iron affects the growth of colon cancer cells and aims to find out how these cells manage to survive with too much iron, which could help develop new treatments for people with colon cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10860973 on NIH RePORTER |
What this research studies
This research investigates the role of iron in the growth and progression of colon cancer. It focuses on understanding how cancer cells accumulate high levels of iron and how this accumulation supports their survival and proliferation. The study aims to identify the mechanisms that allow colon cancer cells to thrive despite the toxic effects of excess iron, potentially leading to new therapeutic strategies. By examining the metabolic pathways involved, the research seeks to uncover targets for iron-based treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colon cancer, particularly those with advanced stages of the disease.
Not a fit: Patients with early-stage colon cancer or those whose cancer is not influenced by iron metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target iron metabolism in colon cancer, improving treatment outcomes.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could be effective.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Shah, Yatrik M — University of Michigan at Ann Arbor
- Study coordinator: Shah, Yatrik M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.