Exploring how codon usage affects mRNA stability
Understanding the relationship between codon optimality and mRNA stability
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11095823
This study is looking at how certain building blocks of genes, called codons, affect the stability of messenger RNA (mRNA) that helps make proteins, which is important for understanding how our bodies work and could lead to new insights for treating diseases like COVID-19.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11095823 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between codon optimality and the stability of messenger RNA (mRNA), which is crucial for protein production in cells. The team will examine how the speed of ribosome movement during protein synthesis influences mRNA degradation, particularly focusing on how different codons affect this process. By understanding these mechanisms, the research aims to uncover new insights into gene expression regulation, which could have implications for various diseases, including COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to mRNA stability, such as certain cancers or viral infections like COVID-19.
Not a fit: Patients with conditions unrelated to mRNA stability or those not affected by viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for manipulating gene expression, potentially benefiting treatments for diseases like COVID-19.
How similar studies have performed: Other research has shown promising results in understanding mRNA dynamics, making this approach both relevant and potentially impactful.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COLLER, JEFFERY — JOHNS HOPKINS UNIVERSITY
- Study coordinator: COLLER, JEFFERY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers