Exploring how circular RNAs affect aging
Official title: Uncovering the functions of circRNAs in aging
Funded at Brandeis University · NIH-11072534 · Data updated 2026-11-12
This study is looking at how certain tiny molecules called circular RNAs might help protect our brains as we age and could lead to new ways to tackle age-related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $660,908 |
| NIH project number | 1R01AG091918-01 |
| Project ID | NIH-11072534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing cognitive decline or those at risk for age-related neurological diseases.
✕Less likely to help
Patients with acute neurological conditions unrelated to aging may not benefit from this research.
What this research studies
This research investigates the role of circular RNAs (circRNAs) in the aging process, particularly their impact on brain function and age-related diseases. By utilizing advanced biochemical and genetic tools, the study aims to uncover how circRNAs regulate gene expression and influence lifespan. The researchers have identified specific circRNAs that may play a protective role against age-related dysfunction, which could lead to new insights into aging mechanisms and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related neurological disorders.
How similar studies have gone: While the role of circRNAs in aging is a relatively novel area of research, preliminary findings suggest potential for significant breakthroughs in understanding age-related diseases.
Where this research is happening
-
Brandeis University
Waltham, United States Active
Researchers
- Principal investigator: Kadener, Sebastian — Brandeis University
- Study coordinator: Kadener, Sebastian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.