Exploring how chronic stress affects asthma in children using advanced genetic techniques
Official title: Understanding Mechanisms Underlying Chronic Stress-Induced Asthma in Children by Population and Single-Cell Epigenomics Approaches
Funded at Children's Mercy Hosp (Kansas City, Mo) · NIH-10835009 · Data updated 2026-11-12
This study is looking at how long-term stress affects asthma in children, especially in African American and Hispanic kids, to understand how tough social situations can impact their health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | August 26, 2020 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $617,464 |
| NIH project number | 5R01MD015409-05 |
| Project ID | NIH-10835009 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-21, especially those from African American and Hispanic communities with a diagnosis of asthma.
✕Less likely to help
Patients who do not have asthma or are outside the age range of 0-21 may not benefit from this research.
What this research studies
This research investigates the relationship between chronic stress and asthma in children, particularly focusing on African American and Hispanic populations who are disproportionately affected. By analyzing genetic changes at the single-cell level and mapping epigenetic modifications in nasal cells, the study aims to uncover how social disadvantages during childhood may lead to long-term health impacts. The research will involve large pediatric asthma cohorts and will assess both asthma severity and the influence of chronic stress on immune responses to viral infections.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for asthma in children, particularly those from disadvantaged backgrounds.
How similar studies have gone: Previous research has shown that understanding the genetic and environmental factors contributing to asthma can lead to significant advancements in treatment, indicating that this approach has potential for success.
Where this research is happening
-
Children's Mercy Hosp (Kansas City, Mo)
Kansas City, United States Active
Researchers
- Principal investigator: Grundberg, Elin — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Grundberg, Elin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.