Exploring how cholesterol production affects the progression of polycystic kidney disease
Investigating intracellular cholesterol biosynthesis as a regulator of polycystic kidney disease progression
This study is looking at how cholesterol production affects the growth of cysts in people with Autosomal Dominant Polycystic Kidney Disease (ADPKD), and it aims to find new ways to slow down the disease by exploring the role of certain proteins in mice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11048929 on NIH RePORTER |
What this research studies
This research investigates the role of cholesterol biosynthesis in the progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD). Researchers are examining how certain proteins, known as sterol regulatory element binding proteins (SREBPs), influence cyst growth in kidney disease. By manipulating these proteins in mouse models, the study aims to identify new therapeutic strategies that could slow down the disease's progression. The findings could lead to innovative treatments that minimize the risks associated with current therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Not a fit: Patients with other forms of kidney disease or those without a diagnosis of ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively slow the progression of polycystic kidney disease with fewer side effects.
How similar studies have performed: Previous studies have shown promising results in manipulating cholesterol pathways in kidney disease models, suggesting potential for success in this approach.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Lakhia, Ronak — Ut Southwestern Medical Center
- Study coordinator: Lakhia, Ronak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.