Exploring how chemicals affect brain development and function
Defining the Chemical Perturbome of Neural Development and Activity
This study is looking at how certain small chemicals affect brain growth and function, using baby zebrafish to help find out which ones might help or hurt brain development, with the goal of discovering new treatments for conditions like autism and intellectual disabilities.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10883966 on NIH RePORTER |
What this research studies
This research investigates how small chemical molecules influence the development and activity of the brain, particularly focusing on their effects on neurons and their connections. By using larval zebrafish as a model organism, the study aims to create a comprehensive 'dictionary' of chemical compounds that can either promote or hinder brain development. The researchers will employ advanced techniques to analyze brain activity and structure, as well as behavioral responses, to identify potential environmental neurotoxins and therapeutic drugs for conditions like autism and intellectual disability.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, such as autism or intellectual disability, or those concerned about environmental exposures.
Not a fit: Patients with fully developed neurological conditions unrelated to neurodevelopmental processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental disorders and better understanding of environmental factors affecting brain health.
How similar studies have performed: While the approach of using chemical screening in zebrafish is established, the specific focus on creating a comprehensive chemical perturbome for neurodevelopment is a novel endeavor.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Thyme, Summer B — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Thyme, Summer B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.