Exploring how chemical modifications affect proteins involved in cancer and other diseases
Official title: Chemical Approaches to Understanding Reversible Lysine Modifications
Funded at Brigham and Women's Hospital · NIH-11059131 · Data updated 2026-11-12
This study is looking at how changes to certain proteins in our cells can affect cancer, and it's for anyone interested in how these changes might help improve cancer treatments and understanding of the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $447,500 |
| NIH project number | 5R35GM149229-03 |
| Project ID | NIH-11059131 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancers or other conditions influenced by histone modifications.
✕Less likely to help
Patients with conditions unrelated to epigenetic modifications or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research focuses on understanding how specific chemical modifications to proteins, particularly histones, influence their function in diseases like cancer. By developing innovative chemical tools, the researchers aim to study the enzymes that add or remove these modifications, which are crucial for regulating gene expression. Patients may benefit from insights gained about how these modifications affect cancer progression and treatment responses. The research employs advanced techniques such as protein semisynthesis and the design of selective inhibitors to explore these biochemical processes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and other diseases by targeting specific protein modifications.
How similar studies have gone: Previous research has shown success in using chemical approaches to study histone modifications, indicating a promising avenue for further exploration.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Cole, Philip a — Brigham and Women's Hospital
- Study coordinator: Cole, Philip a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.