Exploring how chemical changes to proteins affect cell function and disease.
Chemical Approaches to Study Protein Post-translational Modifications
This study is looking at how changes to proteins in our cells, like adding or removing certain chemical tags, can affect how cells work and contribute to diseases like cancer, with the goal of finding new ways to develop better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11074633 on NIH RePORTER |
What this research studies
This research investigates the role of protein post-translational modifications, such as phosphorylation and acetylation, in cellular processes and disease development, particularly cancer. By developing innovative chemical methods, the research aims to uncover how these modifications influence protein function and interactions. The project focuses on creating new tools to better understand the impact of these modifications on cell biology, which could lead to advancements in drug development and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or other diseases where protein post-translational modifications play a significant role.
Not a fit: Patients with conditions unrelated to protein modifications or those not affected by cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating cancers and other diseases linked to protein modifications.
How similar studies have performed: Previous research has shown promise in understanding protein modifications and their implications in disease, indicating that this approach could yield valuable insights.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Pflum, Mary Kay H — Wayne State University
- Study coordinator: Pflum, Mary Kay H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.