Exploring how changes in RNA splicing affect pancreatic cancer
Understanding and targeting mutant splicing factors in pancreatic cancer
This study is looking at how certain changes in RNA splicing factors affect the growth of pancreatic cancer and how well current treatments work, with the hope of finding new ways to help patients with this tough disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10925199 on NIH RePORTER |
What this research studies
This research investigates the role of mutant RNA splicing factors in pancreatic ductal adenocarcinoma (PDAC), a highly aggressive form of cancer. The team aims to understand how these mutations contribute to tumor growth and resistance to existing therapies. By using advanced techniques like genetically engineered mouse models and RNA splicing inhibitors, they hope to identify new therapeutic targets that could improve treatment outcomes for patients with PDAC. The ultimate goal is to develop targeted therapies that specifically address the unique splicing alterations found in these tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma, particularly those with specific RNA splicing mutations.
Not a fit: Patients with other types of cancer or those without the identified RNA splicing mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for pancreatic cancer patients.
How similar studies have performed: Previous research has shown promising results in targeting RNA splicing in cancer, suggesting that this approach could be effective for pancreatic cancer as well.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Escobar Hoyos, Luisa — Yale University
- Study coordinator: Escobar Hoyos, Luisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.