Exploring how changes in gene regulation affect low back pain
Imaging Epigenetic Dysregulation in Patients with Low Back Pain
This study is looking at how changes in the brain might be linked to chronic low back pain, using a special imaging technique to see how certain enzymes related to pain work, with the hope of finding new, non-opioid treatments for people suffering from this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10375955 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic changes in the brain that may contribute to chronic low back pain. By using a specialized imaging technique with a PET agent called [11C]Martinostat, the study aims to visualize and measure the density of specific enzymes linked to pain regulation. Patients with low back pain may have their pain mechanisms better understood, potentially leading to new treatment options that do not rely on opioids. The research involves both imaging studies and analysis of how these epigenetic factors relate to pain experiences.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic low back pain.
Not a fit: Patients with acute pain or those not experiencing low back pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for chronic low back pain.
How similar studies have performed: Other research has shown promising results in using imaging techniques to study pain mechanisms, but this specific approach is relatively novel.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wey, Hsiao-Ying — Massachusetts General Hospital
- Study coordinator: Wey, Hsiao-Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.