Exploring how changes in cell structure affect neurodegenerative diseases like Alzheimer's.
CofActor: Investigation of the Role of Cytoskeletal Dysregulation in Neurodegenerative Disease
['FUNDING_R15'] · EAST CAROLINA UNIVERSITY · NIH-10359367
This study is exploring how problems with cell structure might play a role in Alzheimer's Disease, using a new tool to see how stress affects brain cells, which could help us understand what causes the disease and how to fight it.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EAST CAROLINA UNIVERSITY (nih funded) |
| Locations | 1 site (GREENVILLE, UNITED STATES) |
| Trial ID | NIH-10359367 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cytoskeletal dysregulation in neurodegenerative diseases, particularly Alzheimer's Disease. The team has developed a novel tool called CofActor, which allows researchers to monitor stress levels in cells that may contribute to disease progression. By using this genetically encoded switch, they aim to understand how oxidative stress affects cellular processes and potentially leads to the formation of harmful structures in neurons. This approach combines advanced techniques in cell biology and optogenetics to provide insights into the mechanisms underlying neurodegeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or other related neurodegenerative conditions.
Not a fit: Patients with neurodegenerative diseases not related to cytoskeletal dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases by targeting the underlying cellular mechanisms.
How similar studies have performed: While the specific approach using CofActor is novel, similar research has shown promise in understanding cellular stress responses in neurodegenerative diseases.
Where this research is happening
GREENVILLE, UNITED STATES
- EAST CAROLINA UNIVERSITY — GREENVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUGHES, ROBERT M — EAST CAROLINA UNIVERSITY
- Study coordinator: HUGHES, ROBERT M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease