Exploring how certain viruses exchange genetic material and affect disease severity.
Understanding the Molecular Determinants of Reassortment in Orthobunyaviruses and Phleboviruses.
['FUNDING_OTHER'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10708169
This study is looking at how certain viruses can swap pieces of their genetic material, which helps us understand how they might change and spread to new hosts, and it's important for keeping people healthy during outbreaks.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10708169 on ClinicalTrials.gov |
What this research studies
This research investigates how orthobunyaviruses and phleboviruses, which are types of segmented RNA viruses, exchange genetic material through a process called reassortment. By understanding the molecular mechanisms behind this process, the research aims to predict how these viruses might evolve and potentially jump to new hosts, which is crucial for public health. The study employs genetic techniques to analyze virus behavior in infected cells and assess the impact of genetic changes on virulence. This knowledge could help in developing strategies to combat viral outbreaks.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals affected by viral infections related to orthobunyaviruses and phleboviruses, particularly those with severe symptoms.
Not a fit: Patients with viral infections not related to orthobunyaviruses or phleboviruses may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictions of viral behavior and improved responses to viral infections, ultimately enhancing patient care.
How similar studies have performed: Previous research has shown success in understanding reassortment in other RNA viruses, indicating that this approach could yield valuable insights.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TILSTON-LUNEL, NATASHA LOUISE — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: TILSTON-LUNEL, NATASHA LOUISE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.